From Lab to Lifesaver: The Katalin Karikó Story
The 2023 Nobel Prize in Physiology or Medicine was awarded jointly to Katalin Karikó and Drew Weissman “for their discoveries concerning base modifications that enabled the development of effective mRNA vaccines against COVID-19.” The Royal Swedish Academy of Science was announced on October 2, 2023.
Life and Career
Katalin Kariko (born 29 September 1959) is a Hungarian-born biochemist who has made significant contributions to the field of messenger RNA (mRNA) research. Her groundbreaking work has played a crucial role in the development of mRNA-based vaccines, including the mRNA COVID-19 vaccines.
Katalin Kariko was born in Hungary and later moved to the United States, where she pursued her scientific career. She has worked at the University of Pennsylvania for many years and is currently a Senior Vice President at BioNTech SE, a German biotechnology company known for its collaboration with Pfizer in the development of the COVID-19 vaccine.
Kariko’s research focused on the use of synthetic mRNA to help cells produce specific proteins. Her work paved the way for the development of mRNA-based therapies, particularly in the context of vaccines. One of her key contributions was the discovery of modified nucleosides, specifically pseudouridine, which could be incorporated into mRNA molecules to reduce the body’s immune response to foreign mRNA. This was a critical step in making mRNA-based therapies safer and more effective.
Her groundbreaking discoveries laid the foundation for the development of mRNA vaccines, including the Pfizer-BioNTech and Moderna COVID-19 vaccines. These vaccines have been instrumental in the global effort to combat the COVID-19 pandemic and have been highly effective in preventing illness caused by the SARS-CoV-2 virus.
Award and Legacy
She was awarded the Nobel Prize in Physiology or Medicine was awarded jointly with Drew Weissman “for their discoveries concerning base modifications that enabled the development of effective mRNA vaccines against COVID-19.”
Katalin Kariko’s work has earned her the respect and admiration of her peers in the scientific community. Her research has opened up new possibilities for using mRNA as a tool for treating various diseases beyond COVID-19.
Kariko’s legacy extends to the broader field of mRNA-based therapies. Her discoveries have not only revolutionized vaccine development but have also paved the way for the development of mRNA-based treatments for other diseases, including cancer and genetic disorders.
Katalin Kariko’s journey from her early research on mRNA to her pivotal role in vaccine development serves as an inspiration to aspiring scientists. Her dedication and perseverance in the face of challenges demonstrate the importance of pursuing innovative research in the pursuit of medical advancements.
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